ginsenoside Rb 2
It is a damaran, protopanaxadiol panaxoside:
R 1 = -Glc 2-1 Glc
R2 = -Glc 6-1 Ara (p)
- In mice stressed by immobilization, plasma levels of interleukin-6 decreased. It also decreased in vitro the production of IL-6 from macrophages with epinephrine / norepinephrine. ( Kim2003iii )
- Gssd. Rb 2 , Rd , Rg 1 and Re have a strong inhibitory effect on the production of TNF-α microglia-activated lipopolysaccharides. ( Wu2007deg )
- Gssd. Rb 1 and Rb 2 suppressed TNF-α production in both mouse and human macrophage stimulated lipopolysaccharides with an IC50 of ~ 50 μM, respectively. ~ 25 μM. ( Cho2001vie )
- It reduced the proliferation of mitogens stimulated by mouse spleen T H and B lymphocytes with an IC50 of about 25 μM and also suppressed their IL-2 production with an IC50 of ~ 13.3 μM. ( Cho2002gfp )
- Protected immune cells (spleen in vitro) from damage by γ radiation . ( Lee2006ivr )